Lizobakt for toothache. Lizobakt is an antiseptic for the treatment of diseases of the larynx, oral cavity and gums

P N014179/01-210311

Trade name of the drug:

Lizobakt ®

INN or group name:

lysozyme + pyridoxine

Dosage form:

lozenges

Compound:

one lozenge contains:

Active substance:

lysozyme hydrochloride 20.00 mg

pyridoxine hydrochloride 10.00 mg

Excipients: lactose monohydrate 155.40 mg, gum tragacanth 10.00 mg, magnesium stearate 4.00 mg, sodium saccharin 0.50 mg, vanillin 0.10 mg.

Description:

round tablets of white or white with a yellowish or cream tint with a dividing line on one side.

Pharmacotherapeutic group:

antiseptic

ATX code:

Pharmacological properties

A combined drug whose effect is determined by its constituent components.

Lysozyme is a protein enzyme, used as an antiseptic due to its direct effect on gram-positive and gram-negative bacteria, as well as fungi and viruses, and takes part in the regulation of local nonspecific immunity.

Pyridoxine – has a protective effect on the oral mucosa (has an anti-aphthous effect). Does not affect the pharmacodynamic properties of lysozyme.

Indications for use

Treatment of infectious and inflammatory diseases of the oral mucosa, gums and larynx: gingivitis, stomatitis, catarrhal phenomena in the upper respiratory tract, aphthous ulcers, hermetic lesions (as part of complex therapy), erosion of the oral mucosa of any etiology.

Contraindications

Hypersensitivity, children under 3 years of age.

Hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Use during pregnancy and breastfeeding

Lizobact® can be used during pregnancy and lactation.

Directions for use and doses

The drug is applied topically. The tablets should be slowly dissolved without chewing, keeping the melted mass of the tablet in the mouth for as long as possible until completely dissolved. Children aged 3-7 years are usually prescribed 1 tablet 3 times a day, 7-12 years - 1 tablet 4 times a day. Adults and children over 12 years old – 2 tablets 3-4 times a day.

The course of treatment is 8 days.

Side effects

Allergic reactions.

Overdose

Symptoms of overdose are unlikely and may occur after use in doses significantly higher than therapeutic doses and are manifested by a feeling of numbness, a tingling sensation, and loss of sensation in the upper and lower extremities.

Treatment: drinking plenty of fluids (forced diuresis).

Interaction with other drugs

The drug Lizobact® enhances the effect of antibiotics, including penicillin, chloramphenicol, nitrofurantoin, enhances the effect of diuretics, and weakens the activity of levodopa. Isoniazid, penicillamine, pyrazinamide, immunosuppressants, estrogens and oral contraceptives may increase the need for pyridoxine (antagonism to pyridoxine or increased renal excretion).

special instructions

If allergic reactions occur, you must stop using the drug and consult a doctor.

Release form

Lozenges. 10 tablets in a blister made of PVC/aluminum foil, 1 or 3 blisters along with instructions for use are placed in a cardboard box.

Best before date

Do not use after the expiration date stated on the package.

Storage conditions

At temperatures from 10 to 30 °C. Out of the reach of children!

Conditions for dispensing from pharmacies

Over the counter

Manufacturer

JSC "Bosnalek", Bosnia and Herzegovina. Sarajevo, st. Yukicheva, 53

Lizobact is an antiseptic combination drug used for the treatment of infectious and inflammatory diseases in ENT practice and dentistry.

Active ingredients: Lysozyme, Pyridoxine.

Lysozyme is a protein enzyme used as an antiseptic (direct effect on gram-positive and gram-negative bacteria, fungi and viruses).

Pyridoxine – has a protective effect on the buccal mucosa (has an anti-aphthous effect). Does not affect the pharmacodynamic properties of lysozyme.

Lizobact lozenges are white or white-yellowish in color, round in shape and have a dividing strip. The composition includes two main active ingredients - lysozyme (20 mg) and pyridoxine (10 mg).

Indications for use

What is Lizobact for? According to the instructions, the drug is used in the following cases:

• inflammation of the mucous membrane of the upper respiratory tract;
• erosion of the oral mucosa of various origins;
• gingivitis;
• aphthous ulcerations;
• complex therapy of herpetic lesions of the oral cavity;
• stomatitis.

Instructions for use Lizobact, dosage

The tablets are dissolved until completely dissolved in the oral cavity, according to the instructions, the dosage of Lizobact and the frequency of use depend on age:

• Children from 3 to 7 years old – 1 tablet \ 3 times a day.
• Children from 7 to 12 years old – 1 tablet \ 4 times a day.
• Children over 12 years of age and adults – 2 tablets \ 3-4 times a day.

For adults, the drug should be taken 3-4 times a day, the duration of treatment is up to 8 days.

The tablets should be slowly dissolved without chewing, keeping the melted mass of the tablet in the mouth for as long as possible until completely dissolved.

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Lizobact:

• allergic reactions.

Contraindications

It is contraindicated to prescribe Lizobact in the following cases:

• hereditary lactose intolerance, lactase deficiency or glucose/galactose malabsorption syndrome;
• children under 3 years of age;
• hypersensitivity to the components of the drug.

Overdose

Overdose is unlikely. Symptoms are a feeling of numbness, a tingling sensation, loss of sensation in the upper and lower extremities.

Analogues of Lizobact, price in pharmacies

If necessary, Lizobact can be replaced with an analogue of the active substance - these are the following drugs:

1. Lysozyme + Pyridoxine.

Similar in action:

• Grammidin,
• Dorithricin,
• Lisak,
• Laripront,
• Septefril,
• Septolete,

When choosing analogues, it is important to understand that the instructions for use of Lizobact, price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.

Price in Russian pharmacies: Lizobact lozenges 30 pcs. – from 255 to 311 rubles, according to 485 pharmacies.

Keep away from children. Store at 10-30°C. Shelf life – 5 years.

Conditions for dispensing from pharmacies - without a prescription.

Lysobact is used to increase local immunity of the throat and pharynx. These tablets can be given even to children and pregnant women due to their safe composition.

Description and action

Lysobact belongs to the drugs used in dentistry and otolaryngology practice. It is presented in the form of absorbable tablets, manufactured by Bosnalijek (Bosnia and Herzegovina). The cost of a pack of 30 tablets is 320 rubles, tablets in a pack of 10 cost 130 rubles. They are white or slightly yellowish, round, with a mark for division, a chamfer. It is normal to have a small number of dark spots on the surface of the pills.

The main active substance in the composition is considered to be lysozyme in a dose of 20 mg; it is a safe antiseptic of natural origin.

Lizobact also contains pyridoxine in the form of hydrochloride, or vitamin B6, dose - 10 mg. To form pills and give a more pleasant taste, minor substances are used - lactose, gum, sodium saccharinate, vanillin. The actions of the medicine are as follows:

Lysozyme is an antibacterial agent, a hydrolase enzyme that is able to penetrate microbial cells after the destruction of their walls. Lysozyme is related to the human body because it is produced by the immune system and is present in saliva and nasopharyngeal mucus. In the drug Lizobakt it is produced from chicken egg white, therefore it is of natural origin. This antiseptic acts on gram-positive and gram-negative microbes, causing lysis of their membranes, helps destroy pathogenic fungi, and has strong antiviral activity.

Pyridoxine is a B vitamin, a substance needed by the body that has regenerative properties. It helps the oral mucosa recover faster from damage caused by an infectious process or inflammatory diseases. The vitamin also has an anti-aphthous effect and reduces the risk of developing local allergic reactions.

Indications and absorption specifics

Lysobact can be used by children and adults for any infectious pathologies of the upper respiratory tract.

As an antiseptic, the drug helps against pain and cough, inflammation and redness of the throat, prevents the transition of diseases to the purulent stage and prevents exacerbation of chronic diseases.

Most often, tablets are prescribed for indications such as viral and bacterial pharyngitis and laryngitis.

In ENT practice, the drug is also used for herpetic inflammation of the mouth against the background of herpes simplex, cytomegalovirus and other viral diseases. Indications for the use of Lizobact tablets are also erosive inflammations in the mouth that have any infectious causes. In complex therapy, the drug is used for the following problems:

In dentistry, the medicine improves immunity and prevents relapses of aphthous stomatitis. Also, tablets will be needed for other types of stomatitis, oral thrush, gingivitis, and periodontitis. We must not forget that taking pills for acute bacterial infections is most often concomitant, so giving up antibiotics and synthetic antiseptics is dangerous to your health!

The medicine is quickly absorbed from the gastrointestinal tract, but due to the peculiarities of administration (resorption) it manages to have a full local effect. Active substances in the form of metabolites are deposited in the liver, nerves, muscles, vitamin B6 also penetrates into breast milk. Unused metabolites are excreted in the urine.

Contraindications and side effects

How many and what contraindications are there for treatment with Lysobact? The drug is allowed to be taken from the age of 3 years, although most otolaryngologists and pediatricians recommend it from 1-1.5 years, but in a reduced dosage. The main contraindication is intolerance to the components, allergies to components, including:

During pregnancy, treatment with Lyzobact is possible, as well as during lactation. Only in the 1st trimester of gestation is it better not to abuse any pills, since during this period the formation of fetal organs occurs. When treating nursing mothers, transfer to artificial feeding is not planned.

Side effects are rare, even local reactions develop in isolated cases. Basically, they come down to allergic phenomena - skin rashes, itching, redness, the appearance of red spots, increased photosensitivity of the skin.

The phenomena of allergic pharyngitis are rarely observed - itching of the palate, sore throat, irritation of the throat.

Anaphylactic shock and Quincke's edema are very rare, almost isolated.

In general, Lyzobact is well tolerated, but if an allergy develops, treatment should be discontinued immediately.

Medication instructions and overdose

Lysobact is applied topically, by resorption in the oral cavity. Children over 12 years of age and adults are recommended to use 2 tablets 3-4 times a day. At 7-12 years old, 1 tablet is prescribed four times a day, at 3-7 years old - 1 tablet three times a day. You should not eat or drink within 30-40 minutes after the drug has been absorbed. It is advisable to dissolve the pill in the mouth slowly, without chewing, in order to prolong the contact of the active substances with the mucous membrane. The drug should not be swallowed; this will minimize the therapeutic effect.

The course of treatment for acute diseases is 8 days; for chronic diseases it can be extended at the discretion of the specialist.

There have been no reports of overdose with Lizobact. When taking a number of tablets that seriously exceeds the norm, signs of an overdose of vitamin B6 may occur - numbness of the limbs, tingling, transient sensitivity disorders, allergic phenomena, night cramps. The acidity of the stomach may also increase, resulting in abdominal pain and heartburn. Signs of overdose disappear on their own, since pyridoxine does not accumulate in the body and is eliminated within 8 hours.

Lizobact analogues for children

Laripront is suitable as a substitute for Lyzobact for children: it also contains lysozyme hydrochloride and is not limited for use by age. In practice, the medicine begins to be given after 3-5 years, when the baby can already dissolve the tablet. Prolonged stay in the oral cavity is important for the effect of Laripront or Lizobact, which is best remembered during treatment. If you simply chew the tablet or give it in pieces, the treatment will slow down.

There is 2 times less lysozyme in Laripront; The antiseptic dequalinium chloride takes the place of pyridoxine. The latter fights fungi and bacteria, which makes the medicine no less effective, albeit without a protective effect. It is recommended to take Laripront one piece every 2-3 hours. The product is cheaper.

Most of the other options are prescribed only from 6 years of age. Antiseptics, along with fragrances and flavoring additives, are introduced into tablets resembling candy. This technique makes it easier to treat children.

• Lorcept contains cetylpyridinium chloride. Among pineapple, orange, mint or honey, you can choose the right flavor for everyone. No more than 6 pieces are shown per day.
• Suprima Lor provides assistance with 2,4-dichlorobenzyl alcohol and amylmetacresol. It is given to the patient every 4 hours, and among the tasty options are strawberries and raspberries. You can buy Suprima Lor cheaper than Lizobact.
• Strepsils for children has a similar composition. Strawberry tablets are given in the same way as the previous substitute. You can count on Strepsils from the age of 5.
• Faringosept has been indicated since the age of 3 years. It has a lemon taste, the active substance is ambazon. You should not drink for 3 hours after taking it.
• Septolete in the form of lozenges disinfects due to benzalkonium chloride and thymol, and at the same time slightly soothes a sore throat with menthol and mint essential oil. Eucalyptus oil makes breathing easier. Septolete can be treated from 4 years of age.

For younger children or those who refuse to take solid medicine, sprays and drops are prescribed. An example would be Tonsilgon N drops based on plant extracts. This remedy is suitable after the first year of life.

Analogs and other information

There are few structural analogues of the drug, but pharmacies offer a wide selection of resorption agents with an antiseptic effect:

The drug can be used with any other medications, and it increases the therapeutic effect of treatment with antibiotics such as penicillins, nitrofurans, and chloramphenicol. Taking Lizobact enhances the effectiveness of diuretic therapy. It is known that undergoing a course of treatment may reduce the absorption of Levodopa. Some medications increase the need for vitamin B6, and resorption of Lysobact can partially replenish it. We are talking about oral contraceptives, immunosuppressive drugs, Isoniacid.

Lizobact is a powerful antiseptic that has gained immense popularity in dentistry. The medicine is intended for the treatment of infectious and inflammatory processes on the mucous membrane of the oropharynx, gums, and larynx.

It has a suppressive effect on pathogenic microflora during infections, eliminating sore throats. Restores the integrity of the structure of the mucous membrane of the oropharynx.

Lyzobact belongs to the group of immunomodulators due to lysozyme, a natural enzyme that is part of the drug. It has an important function as a regulator of local immunity. This ensures rapid recovery, relief of inflammation and elimination of swelling.

Release form and composition

The medication is produced in the form of small tablets packaged in blisters. The drug package consists of 30 tablets.

The medicine may vary in appearance from white to white-yellowish. Each tablet has a round shape, with a dividing line in the middle. The main components that have the main therapeutic effect are lysozyme (20 mg) and pyridoxine (10 mg).

Auxiliary components included in the composition of Lizobact tablets:

• lactose monohydrate;
• gum tragacanth;
• sodium saccharinate;
• magnesium stearate;
• vanillin.

Pharmacological profile

The drug has a powerful antimicrobial effect. Easily deals with bacteria, fungi, microbes and some viral forms.

Lysozyme is a component of healthy human saliva. When the content of this substance in saliva is sufficient, the latter has a disinfecting effect on the oral cavity.

Immunity is formed naturally, preventing the penetration of pathogenic microorganisms into the oropharynx. But when there is insufficient production of lysozyme, or injury to the mucous membrane occurs, the protective functions of saliva are suppressed. Infections easily penetrate and it’s time to seek help from this medicine.

The mucous membrane begins to collapse under the pressure of infection, and metabolic processes are disrupted. Pyridoxine is responsible for the healing effect.

Indications and contraindications for use

Due to its powerful immunomodulatory effect, Lysobact is popular and widely used in dentistry and otolaryngology.

Indications for use:

• – bacterial inflammation of the mucous membrane;
• erosions, damage in the oropharynx;
• swelling, redness, pain, sore throat;
• cough.

Can it be used for sore throat?

There are no direct instructions in the instructions for Lizobakt about the treatment of sore throat, but there are for tonsillitis. Both diseases are accompanied by the same symptoms: pain, swelling of the throat, inflammation of the tonsils, and the formation of purulent plaques.

Accordingly, taking the drug for a sore throat is not only possible, but even necessary. But in this case it is better to supplement treatment with antibiotics. Then the drug will increase its effect.

Sore throat is a disease that is serious and cannot be cured with one drug, even a very good one. But you can strengthen your immune system well, which in itself leads to recovery.

In some cases, the use of the medication is not recommended:

• malabsorption disorders;
• disturbances in the digestion of some carbohydrates;
• in case of individual intolerance to individual components;
• children under three years of age;
• Lizobact is prescribed with caution to children under three years of age, during pregnancy and breastfeeding.

Application diagram

The tablets must be placed under the tongue, without dissolving, until they are completely dissolved. For each age group a certain dosage is assumed:

1. 3-7 years. One tablet - three times.
2. 7-12 years. One tablet - four times.
3. Over 12 years old. Two tablets - four times.

Treatment lasts for 7-12 days, the timing is directly dependent on the nature and form of the disease.

special instructions

When using Laripront, you should consider the following points:

• the medicine has an enhancing effect on the work of antibiotics;
• during therapy, the effect of diuretics increases;
• taking estrogens and oral contraceptives has a suppressive effect on pyridoxine, so you may need to increase the dosage of the medication;
• after the medicine has completely dissolved, it is not recommended to eat or drink for the next half hour;
• during pregnancy and lactation, taking the medicine is allowed;
• at the slightest suspicion of an allergy, you should immediately stop taking the drug;
• there is no data on the effect of the drug on psychomotor functions;
• available without a prescription.

Special patients

Reception of Lizobakt by special groups of patients:

Side effects

Side effects of the drug were reported extremely rarely. Basically, these are allergic manifestations:

• hives;
• skin rash;
• skin hyperemia.

The first use of a medication may provoke an allergic reaction. If this happens, you should immediately consult a doctor to adjust the dosage or replace the medication.

Practical application experience

Reviews from patients and doctors' point of view regarding the effectiveness of Lizobact tablets.

I often suffer from sore throats. I took this drug as prescribed as an additional therapy. It was possible to significantly alleviate the condition and relieve severe pain. After three days of taking it I was already feeling a little better.

Karina, 23

The child has a sore throat. The doctor prescribed this medicine. I was very pleased with the effectiveness of the treatment. The child literally stopped complaining of pain on the first day.

The price of this medicine is considerable, but one pack is enough for the entire course. Now I always buy these tablets, treat all family members with them and am always surprised by its effectiveness.

Nina Karimovna, 42

The medication really treats inflammation of the oropharynx well, relieves redness, pain, and swelling. Children don't mind taking it. The tablets are small and have a pleasant taste. This drug, as an auxiliary drug, works quite well for many diseases.

Local therapist

This product has a good and balanced composition; the content of lysozyme is especially pleasing. This substance compensates for its deficiency in human saliva. And the body itself begins to fight infections. This remedy occupies a special place in my list of effective medicines.

General doctor

What can be replaced?

Any medicine should give a positive result in the first seven days of its use. If this does not happen, it's time to look for a replacement.

Effective analogues that are similar in their effects to Lyzobact:

The use of any of these remedies completely eliminates the consumption of alcoholic beverages.

Main competitors

Let's compare Lizobact with Laripront and Faringosept.

The first two medications have similar therapeutic effects. They are characterized by strong antimicrobial properties. But Laripront also thins sputum and eliminates bleeding.

In terms of indications, both drugs are practically the same. According to Laripront's instructions, it is only clear that the medicine must be taken every three hours, and a more detailed dosage is prescribed by the doctor.

For Lyzobact, the official instructions describe a detailed dosage regimen. Due to the similarity of the drugs, the main advantage of Laripront is its reasonable cost.

Faringosept also treats infectious and inflammatory diseases of the oropharynx and is prescribed for pharyngitis.

The main differences are the absence of interaction between Faringosept and other medications, while the first two have an enhancing effect on the work of antibiotics.

In terms of price, Lizobact is much more expensive than its competitors.

Cost and storage

The cost of this medicine depends on the pricing policy of the pharmacy chain that sells it. But the average price will be at least 320 rubles.

In online pharmacies, the product is cheaper, but its pharmacological properties do not weaken because of this.

From the moment of production of the drug, a shelf life of up to five years is allowed with the preservation of all its properties. It is recommended to store the medicine at a temperature not lower than 10C and not higher than 30C.

Lozenges - 1 tablet:

active ingredients: lysozyme hydrochloride - 20 mg; pyridoxine hydrochloride - 10 mg;
• excipients: lactose monohydrate - 155.4 mg; gum tragacanth - 10 mg; magnesium stearate - 4 mg; sodium saccharinate - 0.5 mg; vanillin - 0.1 mg

Lozenges. 10 tablets each in a PVC/aluminum foil blister. 1 or 3 bl. placed in a cardboard box.

Description of the dosage form

Lozenges: round, white or yellowish-white with a score line on one side and a chamfer on both sides. Inclusions in the form of dark dots are possible.

pharmachologic effect

Antiseptic.

Pharmacodynamics

A combined drug whose effect is determined by its constituent components.

Lysozyme is a protein enzyme, used as an antiseptic due to its direct effect on gram-positive and gram-negative bacteria, as well as fungi and viruses; takes part in the regulation of local nonspecific immunity.

Pyridoxine has a protective effect on the oral mucosa (has an anti-aphthous effect). Does not affect the pharmacodynamic properties of lysozyme.

Indications for use of Lizobact

Treatment of infectious and inflammatory diseases of the oral mucosa, gums and larynx: gingivitis; stomatitis; catarrhal phenomena in the upper respiratory tract; aphthous ulcerations; herpetic lesions (as part of complex therapy); erosion of the oral mucosa of any etiology.

Contraindications to the use of Lizobact

• hypersensitivity;
• hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption;
• children under 3 years of age.

Lizobakt Side effects

Allergic reactions.

Drug interactions

The drug Lizobakt enhances the effect of antibiotics, incl. penicillin, chloramphenicol, nitrofurantoin, diuretics, weakens the activity of levodopa. Isoniazid, penicillamine, pyrazinamide, immunosuppressants, estrogens and oral contraceptives may increase the need for pyridoxine (antagonism to pyridoxine or increased renal excretion).

Lizobact dosage

The tablets should be slowly dissolved without chewing, keeping the melted mass of the tablet in the mouth for as long as possible until completely dissolved.

Children aged 3–7 years are usually prescribed 1 tablet. 3 times a day, 7–12 years - 1 tablet. 4 times a day. Adults and children over 12 years old - 2 tablets each. 3–4 times a day.

The course of treatment is 8 days.

Overdose

Symptoms: unlikely, may occur after use in doses significantly higher than therapeutic, and are manifested by a feeling of numbness, a tingling sensation, and loss of sensation in the upper and lower extremities.

Treatment: drinking plenty of fluids (forced diuresis).