Octolipen for infusion - instructions for use. Octolipen for infusion - instructions for use Effect on the ability to drive vehicles and operate complex machinery
Octolipen is a neuroprotective, hepatoprotective, hypoglycemic, hypolipidemic and hypocholesterolemic drug. A drug of the pharmacological group of vitamin-like substances.
The active ingredient of the drug, thioctic (α-lipoic) acid, is an antioxidant that blocks free radicals, prevents liver disease and the formation of fatty plaques on the walls of blood vessels. With age, the human body produces it in ever smaller quantities.
A vitamin-like substance - thioctic acid - increases the body's sensitivity to insulin and tableted hypoglycemic drugs, lowers blood sugar levels, and also helps normalize fat and carbohydrate metabolism.
Clinical and pharmacological group
Neuroprotective, hypoglycemic, hypocholesterolemic, hepatoprotective and hypolipidemic agent.
Conditions for dispensing from pharmacies
Dispensed with a doctor's prescription.
Prices
How much does Octolipen 600 mg cost in pharmacies? The average price is 700 rubles for 30 tablets.
Release form and composition
The drug is available in several forms (capsules, tablets, injection solution). The choice of the type of drug depends on the characteristics of the patient’s body and the nature of the disease. The main functions of Octolipen are performed by thioctic acid, which is the main component.
The following substances are added to tablets and capsules:
- calcium hydrogen phosphate dihydrate;
- medical gelatin;
- magnesium stearate;
- titanium dioxide;
- silica;
- dye.
Tablets and capsules differ in color. The dose of the active substance in them is 300 and 600 mg. Sold in packs of 30 and 60 units.
The infusion solution is liquid, colorless and transparent.
Auxiliary components of its composition are:
- water;
- disodium edetate;
- ethylenediamine.
For convenience, this type of Octolipen is placed in ampoules.
Pharmacological effect
Thioctic or alpha lipoic acid acts as a natural antioxidant produced by the body of every person, which is a link for free radicals. Also, under its influence, the production of intracellular glutathione is restored, the activity of superoxide dismutase increases, the nutrition of neurons improves, as does axonal conductivity.
The Russian drug Octolipen helps reduce the concentration of glucose in the blood, and glycogen in the liver, on the contrary, increases. Experts note a pronounced effect in overcoming insulin resistance. By the nature of its action in terms of biochemistry, thioctic acid is similar to B vitamins.
You can find out why Octolipen is prescribed from the instructions. It is suitable for the treatment of diabetes, but there are other pathologies for which it is needed. A doctor must prescribe the medicine. He can assess how appropriate it is to use it in a given situation, select the correct dosage and monitor the progress of treatment.
Indications for use
Indications for use of Octolipen in the form of capsules of 300 and 600 mg:
- polyneuropathy of diabetic origin;
- polyneuropathy of alcoholic origin.
Indications for use of Octolipen in the form of a solution for infusion of 12 and 25 mg:
- fatty liver;
- chronic hepatitis;
- intoxication;
- hyperlipidemia;
- hepatitis A;
- poisoning with toadstool.
Contraindications
Contraindications to the use of the drug are as follows:
- hypersensitivity to the components of the drug;
- pregnancy;
- lactation period;
- childhood.
Use during pregnancy and lactation
The use of the drug Octolipen during pregnancy and lactation is contraindicated.
Dosage and method of administration
The instructions for use indicate that Octolipen capsules and tablets are taken orally, on an empty stomach, half an hour before breakfast, without chewing or breaking, with a sufficient amount of liquid.
It is recommended to take the drug once a day at a dose of 600 mg (2 capsules/1 tablet). In some cases, it is possible to prescribe stepwise therapy: during the first 2–4 weeks of the course, thioctic acid is administered intravenously in the form of infusions (using concentrate), and then tablets are taken in a standard dose.
The duration of therapy is determined by the doctor. Octolipen 600 mg tablets are not recommended to be taken for more than 3 months, but if necessary, as prescribed by a doctor, the use of the drug can be longer.
Concentrate for the preparation of solution for infusion
To prepare the solution, use 1-2 ampoules, which are diluted in 50-250 ml of 0.9% sodium chloride solution. After preparation, it is administered intravenously. The standard dose is 300-600 mg per day.
The drug is sensitive to light, so ampoules should be removed only immediately before use. At this time, it is also advisable to protect the bottle from sunlight. The prepared solution should be stored in a place well protected from light and no longer than 6 hours after preparation.
Side effects
The following side effects may occur when using this medicine:
- Gastrointestinal tract (if taken orally): extremely rarely - diarrhea, nausea, heartburn, vomiting, abdominal pain;
- Metabolism: extremely rarely - a decrease in blood glucose levels, the appearance of symptoms of hypoglycemia (due to improved glucose absorption) in the form of increased sweating, dizziness, headache, blurred vision;
- Allergic reactions: extremely rare - urticaria, itching, skin rash, systemic reactions (including anaphylactic shock);
- Blood coagulation system: with intravenous administration - hemorrhagic rash (purpura), pinpoint hemorrhages in the mucous membranes, skin, thrombocytopathy, thrombophlebitis;
- Nervous system: extremely rare - change/disturbance in taste sensations (with oral administration), diplopia, convulsions (with intravenous infusion);
- Other: with rapid intravenous administration - difficulty breathing, increased intracranial pressure (feeling of heaviness in the head).
Overdose
In case of an overdose of the drug, nausea, vomiting, and headache develop. In severe cases, psychomotor agitation, hypoglycemia (up to hypoglycemic coma), clouding of consciousness, generalized convulsions, suppression of bone marrow activity, skeletal muscle necrosis, multiple organ failure, and impaired blood coagulation are observed.
If an overdose is suspected, the patient requires urgent hospitalization and intensive care. There is no specific antidote. Hemoperfusion and hemodialysis are not effective in this situation.
special instructions
In patients with diabetes mellitus, frequent monitoring of blood glucose concentrations is necessary, especially at the beginning of treatment. In some cases, a reduction in the dose of hypoglycemic agents is required.
During treatment, you must strictly abstain from drinking alcohol, because... ethanol reduces the therapeutic effectiveness of thioctic acid.
Drug interactions
Thioctic acid binds metals, so it should not be taken together with medications containing iron, magnesium, or calcium. According to the instructions, the tablets are taken 30 minutes before meals. Taking medications containing metals should be postponed until the afternoon. Because of this property of thioctic acid, dairy products should also be consumed in the afternoon or evening.
The effect of the antioxidant on the central nervous system is minimal, but doctors recommend refraining from driving or operating complex machinery immediately after taking it.
Octolipen is a drug that improves the condition of nervous tissue. Its main active substance is a-lipoic acid (thioctic acid). Normally, this compound is produced in the human body itself, maintaining its health (similar to B vitamins).
Treatment with Octolipen is primarily aimed at normalizing the nutrition and functions of nervous tissue in polyneuropathies (impaired functioning of peripheral nerves, expressed in impaired sensitivity).
In this article we will look at why doctors prescribe Octolipen, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Octolipen can be read in the comments.
Composition and release form
Clinical and pharmacological group: a drug with an antioxidant effect that regulates carbohydrate and lipid metabolism.
You can find the drug "Octolipen" on the open market. Capsules are the most preferred form. Each contains 300 mg of lipoic acid. It is enclosed in a convenient gelatin shell that does not need to be damaged; you just need to wash the capsule down with water.
The second option is “Octolipen” tablets. The active substance is the same - lipoic acid in the amount of 600 mg. That is, if it is necessary to increase the dosage, this may be the best option. Excipients are calcium, silicon and starch. They are necessary to give shape.
What does Octolipen help with?
The drug Octolipen is part of complex therapy for:
- poisoning, including mushrooms, salts of heavy metals, etc.;
- chronic and acute inflammatory disorders of the liver (cirrhosis, hepatitis);
- degenerative and dystrophic changes in the nervous system of various etymologies, including diabetic and alcoholic polyneuropathy, neuralgia;
- critically elevated levels of cholesterol, triglycerides in the blood, as well as other disorders of lipid and lipoprotein metabolism.
Pharmacological properties
Octolipene has a pronounced protective effect against toxic products formed in the body as a result of oxidation reactions. It does not allow superoxide anion and other damaging substances to negatively affect the condition of cell membranes.
Thioctic acid is a coenzyme that participates in the reaction of elimination of the carboxyl group from keto acids. Lowers blood sugar by storing it in the form of glycogen. Reduces insulin tolerance. Improves metabolism. It has a positive therapeutic effect in the treatment of diffuse peripheral damage to nerve fibers.
The listed properties make it possible to use Octolipen as a means to normalize liver function, break down lipids, reduce blood glucose levels, and prevent vascular atherosclerosis. Thanks to thioctic acid, trophic interactions between neurons and nerve conduction in axonal disorders are normalized. Octolipen smoothes out the manifestations of polyneuropathy in diabetics and people with alcohol dependence.
Instructions for use
For those who have been prescribed Octolipen 600 capsules or tablets, the instructions for use include taking the daily dose in the morning on an empty stomach half an hour before meals. Concomitant consumption of food reduces the effectiveness of the drug. Chewing and crushing tablets and capsules is also not recommended.
- Recommended dose – 1 tablet. (600 mg) 1 time/day.
It is possible to carry out stepwise therapy: oral administration of the drug begins after a 2-4-week course of parenteral administration of thioctic acid. The maximum course of taking tablets is 3 months. In some cases, therapy with Octolipen requires longer-term use. The duration of treatment is determined by the attending physician.
Contraindications
Octolipen is not prescribed to patients with personal intolerance to the active or additional components of tablets and capsules. Octolipen is not used in pediatric practice.
Patients with diabetes mellitus should take the drug Octolipen with caution (due to the enhanced effect of antidiabetic drugs and an increased risk of hypoglycemia).
Side effects
Since the main component of the medicine is “natural” for the body, it rarely causes unwanted effects. In very rare cases this may be:
- Taste disturbances;
- Digestive disorders, nausea, heartburn, abdominal pain;
- Hypoglycemia;
- Hives.
Pregnancy and lactation
Octolipen is not recommended for pregnant and lactating women, since at the moment there is no accurate information about how its use affects the development of the fetus and whether it affects breast milk.
Analogs
The following drugs have a similar effect to Octolipen:
- Lipoic acid;
- Alpha lipone;
- Neurolipon;
- Dialipon;
- Thiogamma;
- Tiogamma Turbo (parenteral solution);
- Thioctacid;
- Tioktodar;
- Tio-Lipon-Novopharm;
- Berlition 600;
- Espa-Lipon.
Attention: the use of analogues must be agreed with the attending physician.
Prices
The average price of OCTOLIPEN, tablets in pharmacies (Moscow) is 620 rubles.
Terms of sale
Dispensed in pharmacies strictly according to a doctor's prescription.
- Maria
I have been suffering from type 2 diabetes for 13 years. Two years ago, a complication arose - polyneuropathy of the lower extremities. I experienced severe pain and numbness in my legs. Sensitivity was almost completely lost. Even in warm weather, my feet were cold. The doctor prescribed a course of treatment with Octolipen. At the beginning of treatment, my sugar dropped, but the endocrinologist changed the dose of insulin, and everything returned to normal. The drug helped me."
- Nonna
I was in neurology with a diagnosis of facial nerve neuropathy. In addition to the main treatment, I was given octolipene (according to m/s). A cloudy yellow solution was poured from a syringe into a bottle with a solution of magnesium sulfate and dripped rapidly. A minute later I felt a heaviness under my sternum and the frontal part of my head. After this drip, I felt heaviness and weakness. The doctor came in quickly and left - smile, close your eyes. By the time I opened my eyes, she was no longer in the room. I was discharged from the hospital and then ended up in pulmonology with atypical pneumonia, sarcoidosis is in question. They can’t determine the cause, now it’s on hormones. And there is no improvement.
A drug with an antioxidant effect that regulates carbohydrate and lipid metabolism
Active substance
Thioctic acid (α-lipoic acid)
Release form, composition and packaging
Film-coated tablets from light yellow to yellow, oval, biconvex, with a notch on one side; on the fracture from light yellow to yellow.
Excipients: low-substituted hyprolose (low-substituted hydroxypropylcellulose) - 108.88 mg, hyprolose (hydroxypropylcellulose) - 28.04 mg, croscarmellose (croscarmellose sodium) - 24.03 mg, colloidal silicon dioxide - 20.025 mg, magnesium stearate - 20.025 mg.
Shell composition: Opadry yellow (OPADRY 03F220017 Yellow) - 28 mg (hypromellose (hydroxypropyl methylcellulose) - 15.8 mg, macrogol 6000 (polyethylene glycol 6000) - 4.701 mg, titanium dioxide - 5.27 mg, talc - 2.019 mg, quinoline yellow aluminum varnish (E104) - 0.1 62 mg , iron oxide yellow dye (E172) - 0.048 mg).
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (6) - cardboard packs.
10 pieces. - contour cell packaging (10) - cardboard packs.
pharmachologic effect
Enhances the effect of insulin and oral hypoglycemic drugs (dosage adjustment is necessary, as well as regular monitoring of blood glucose levels to avoid hypoglycemia).
Simultaneous use of the drug Octolipen and preparations of iron, magnesium and calcium is not recommended (due to the formation of a complex with metals). The interval between doses should be at least 2 hours.
Ethanol and its metabolites weaken the therapeutic activity of thioctic acid.
special instructions
During treatment (especially at the initial stage), regular monitoring of blood glucose levels in patients with diabetes mellitus is necessary. In some cases, it may be necessary to reduce the dose of insulin or oral hypoglycemic drug to avoid the development of hypoglycemia.
Patients taking Octolipen should avoid drinking alcohol.
Concomitant food intake may interfere with the absorption of the drug.
When taking Octolipen, consumption of dairy products is not recommended (due to their calcium content). The interval between doses should be at least 2 hours.
Impact on the ability to drive vehicles and operate machinery
The effect on the ability to drive vehicles and machinery has not been specifically studied. Necessary
exercise caution when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Pregnancy and lactation
The use of the drug during pregnancy is contraindicated due to the lack of sufficient clinical experience with the use of thioctic acid in pregnant women. Reproductive toxicity studies did not reveal any risks to fertility, effects on fetal development or any embryotoxic properties of the drug.
The use of Octolipen during lactation is contraindicated due to the lack of data on the penetration of thioctic acid into breast milk.
Use in childhood
The use of the drug in children and adolescents under 18 years of age is contraindicated (efficacy and safety have not been established).
Conditions for dispensing from pharmacies
The drug is available with a prescription.
Storage conditions and periods
The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 2 years.
In this article you can read the instructions for use of the drug Octolipen. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Octolipen in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Octolipene in the presence of existing structural analogues. Use for the treatment of hepatitis, liver cirrhosis and weight loss in adults, children, as well as during pregnancy and lactation. Composition of the drug.
Octolipen- endogenous antioxidant (binds free radicals), formed in the body during the oxidative decarboxylation of alpha-keto acids. As a coenzyme of mitochondrial multienzyme complexes, it participates in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Helps reduce blood glucose and increase glycogen content in the liver, as well as overcome insulin resistance. By the nature of its biochemical action, thioctic acid is close to B vitamins. It participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, and improves liver function.
It has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effects. Improves neuronal trophism and axonal conduction, reduces the manifestations of diabetic and alcoholic polyneuropathy.
Compound
Thioctic (alpha-lipoic) acid + excipients.
Pharmacokinetics
When taken orally, it is quickly and completely absorbed; taking it with food reduces absorption. Bioavailability - 30-60% due to the “first pass” effect through the liver. Metabolized in the liver by side chain oxidation and conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%).
Indications
- diabetic polyneuropathy;
- alcoholic polyneuropathy;
- cirrhosis of the liver;
- hepatitis (chronic hepatitis);
- prevention and treatment of atherosclerosis (hypolipidemic effect);
- weight loss (due to normalization of fat metabolism);
- fatty liver;
- intoxication (including salts of heavy metals), poisoning with toadstool.
Release forms
Capsules 300 mg.
Film-coated tablets 600 mg.
Concentrate for the preparation of a solution for infusion (injections in injection ampoules).
Instructions for use and dosage regimen
Capsules
The drug is taken orally, on an empty stomach, 30 minutes before the first meal, without chewing and with a sufficient amount of water.
The duration of the course of treatment is determined by the doctor.
Pills
The drug is taken orally, on an empty stomach, 30 minutes before meals. The tablets should be swallowed whole, without chewing, with a sufficient amount of liquid.
It is possible to carry out stepwise therapy: oral administration of the drug begins after a 2-4-week course of parenteral administration of thioctic acid. The maximum course of taking tablets is 3 months. In some cases, therapy with Octolipen requires longer-term use. The duration of treatment is determined by the attending physician.
Ampoules
To prepare an infusion solution, 1-2 ampoules (300-600 mg) of the drug are diluted in 50-250 ml of 0.9% sodium chloride solution. The prepared solution is administered intravenously (in the form of a dropper). Apply 300-600 mg 1 time per day for 2-4 weeks. Subsequently, they switch to oral therapy.
The drug is photosensitivity, so the ampoules should be removed from the packaging only immediately before use. It is advisable to protect the bottle with the solution from light during the infusion (light-protective bags or aluminum foil can be used). The prepared solution must be stored in a place protected from light and used within a maximum of 6 hours after preparation.
Side effect
- hives;
- systemic allergic reactions (up to the development of anaphylactic shock);
- development of symptoms of hypoglycemia (due to improved glucose absorption);
- convulsions;
- diplopia;
- pinpoint hemorrhages in the mucous membranes, skin;
- thrombocytopathy;
- hemorrhagic rash (purpura);
- thrombophlebitis;
- with rapid intravenous administration, intracranial pressure may increase (a feeling of heaviness in the head), difficulty breathing;
- nausea, vomiting;
- heartburn;
- abdominal pain;
- diarrhea.
Contraindications
- pregnancy;
- lactation period (breastfeeding);
- children and adolescents under 18 years of age (efficacy and safety of use have not been established);
- hypersensitivity to the components of the drug.
Use during pregnancy and breastfeeding
The use of the drug Octolipen during pregnancy and lactation is contraindicated.
Use in children
Contraindicated in children and adolescents under 18 years of age (efficacy and safety have not been established).
special instructions
In patients with diabetes mellitus, frequent monitoring of blood glucose concentrations is necessary, especially at the beginning of treatment. In some cases, a reduction in the dose of hypoglycemic agents is required.
During treatment, you must strictly abstain from drinking alcohol, because... ethanol reduces the therapeutic effectiveness of thioctic acid.
Drug interactions
Octolipene (in the form of a solution for infusion) leads to a decrease in the effect of cisplatin.
When used simultaneously with insulin and/or oral hypoglycemic agents, an increase in the hypoglycemic effect is observed.
Thioctic acid forms sparingly soluble complex compounds with sugar molecules. The prepared solution is incompatible with glucose solution, levulose, Ringer's solution, as well as with compounds (including their solutions) that react with disulfide and SH groups.
Analogues of the drug Octolipen
Structural analogues of the active substance:
- Alpha lipoic acid;
- Berlition 300 and 600;
- Lipamide tablets;
- Lipoic acid;
- Lipothioxone;
- Neurolipon;
- Thiogamma;
- Thioctacid 600;
- Thioctic acid;
- Thiolepta;
- Thiolipon;
- Espa Lipon.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
Trade name:
Octolipen*
International nonproprietary name:
Thioctic acid
Chemical name:
5-[(3K5)-1,2-Dithiolan-3-yl]pentanoic acid
Dosage form:
film-coated tablets
Composition per tablet
Active substance; thioctic acid (ct-lipoic acid) - 600.0 mg. Excipients:
core: low-substituted hyprolose (low-substituted hydroxypropylcellulose) -108.880 mg, hyprolose (hydroxypropylcellulose) 28.040 mg. croscarmellose (croscarmellose sodium) - 24.030 mg, colloidal silicon dioxide - 20.025 mg, magnesium stearate - 20.025 mg;
shell: Opadry yellow (OPADRY 03F220017 Yellow) - 28,000 mg [hypromellose (hydroxypropyl methylcellulose) - 15,800 mg, macrogol-6000 (polyethylene glycol 6000) -4,701 mg, titanium dioxide - 5,270 mg, talc - 2,019 mg, quinoline yellow aluminum varnish ( E 104 ) - 0.162 mg, iron dye yellow oxide (E 172) - 0.048 mg].
Description:
film-coated tablets from light yellow to yellow, oval, biconvex with a score on one side. On the fracture it is light yellow to yellow.
Pharmacotherapeutic group:
metabolic agent.
ATX code: A16AX01
Pharmacological properties
Pharmacodynamics
Thioctic (a-lipoic acid) acid is found in the human body, where it functions as a coenzyme in the oxidative phosphorylation reactions of pyruvic acid and alpha-keto acids. Thioctic acid is an endogenous antioxidant. Thioctic acid helps protect cells from the toxic effects of free radicals arising in metabolic processes and neutralizes exogenous toxic compounds. Thioctic acid increases the concentration of the endogenous antioxidant glutathione, which leads to a decrease in the severity of symptoms of polyneuropathy. The drug has hepatoprotective properties. hypolipidemic, hypocholesterolemic, hypoglycemic effects; improves neuronal trophism. The result of the synergistic effect of thioctic acid and insulin is an increase in glucose utilization. Pharmacokinetics
When taken orally, it is quickly and completely absorbed from the gastrointestinal tract; taking it simultaneously with food may reduce the absorption of the drug. Taking the drug, according to the recommendations, 30 minutes before meals allows you to avoid unwanted interactions with food, since the absorption of thioctic acid is already complete at the time of eating. The maximum concentration of thioctic acid in the blood plasma is reached 30 minutes after taking the drug and is 4 mcg/ml. Thioctic acid has a “first pass” effect through the liver. The absolute bioavailability of thioctic acid is 20%. The main metabolic pathways are oxidation and conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). Half-life (T1/2) - 25 minutes.
Indications for use
Diabetic polyneuropathy, alcoholic polyneuropathy.
Contraindications
Hypersensitivity to thioctic acid or other components of the drug. Pregnancy and breastfeeding (there is no sufficient experience in using the drug).
Children under 18 years of age (efficacy and safety of use have not been established).
Use during pregnancy and breastfeeding
The use of the drug during pregnancy is contraindicated due to the lack of sufficient clinical experience with the use of thioctic acid during pregnancy. Reproductive toxicity studies did not reveal any risks to fertility, effects on fetal development or any embryotoxic properties of the drug.
The use of Octolipen during breastfeeding is contraindicated due to the lack of data on the penetration of thioctic acid into breast milk.
Directions for use and doses
In some (severe) cases, treatment begins with the prescription of the drug Octolipen solution for intravenous administration for 2-4 weeks, then transferred to treatment with the oral form of the drug Octolipen® (stepped therapy). The type and duration of therapy is determined by the doctor.
Side effect
The incidence of side effects is determined as follows:
Very common: > 1/10;
Often:<1/10> 1/100;
Infrequently:<1/100> 1/1000;
Rarely:<1/1000> 1/10000;
Very rarely:<1/10000.
From the gastrointestinal tract: often - nausea; very rarely - vomiting, pain in
areas of the stomach and intestines, diarrhea, changes in taste.
Allergic reactions: very rarely - skin rash, urticaria, itching, anaphylactic
From the nervous system and sensory organs: often - dizziness.
General: very rare - due to improved glucose utilization, blood glucose levels may decrease and symptoms of hypoglycemia may appear (confusion, increased sweating, headache, visual disturbances).
Overdose
Symptoms
In the case of taking thioctic (a-lipoic) acid in doses of 10-40 g, serious signs of intoxication may be observed (generalized convulsions; severe acid-base imbalance leading to lactic acidosis; hyperglycemia, up to hypoglycemic coma; severe blood clotting disorders, sometimes leading to to a fatal outcome). If a significant overdose of the drug is suspected (doses equivalent to more than 10 tablets for an adult or more than 50 mg per kg of body weight for a child), immediate hospitalization is necessary.
Treatment: there is no specific antidote. Treatment is symptomatic, if necessary, anticonvulsant therapy, measures to maintain the functions of vital organs.
Interaction
With the simultaneous administration of thioctic acid and cisplatin, a decrease in the effectiveness of cisplatin is observed. Thioctic acid binds metals, so it should not be administered concomitantly with drugs containing metals (for example, iron, magnesium, calcium). According to the recommended method of administration, Octolipen tablets are taken 30 minutes before breakfast, while drugs containing metals should be taken at lunchtime or in the evening. For the same reason, during the treatment period, it is recommended to consume dairy products only in the afternoon.
With simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs, their effect may be enhanced, therefore regular monitoring of blood glucose levels is recommended, especially at the beginning of therapy with thioctic acid. In some cases, it is permissible to reduce the dose of hypoglycemic drugs to avoid the development of symptoms of hypoglycemia. Ethanol and its metabolites weaken the effect of thioctic acid.
special instructions
Patients taking Octolipen® should refrain from drinking alcoholic beverages, since alcohol consumption is a risk factor for the development of polyneuropathy and may reduce the effectiveness of treatment. Treatment of diabetic polyneuropathy should be carried out while maintaining optimal blood glucose concentrations.
Impact on the ability to drive vehicles and machinery
The effect on the ability to drive vehicles and machinery has not been specifically studied. Care must be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Release form
Film-coated tablets, 600 mg.
10 tablets per blister pack made of polyvinyl chloride film or imported PVC/PVDC. or PVC/Polyethylene/PVDC and printed varnished aluminum foil.
3, 6, 10 blister packs along with instructions for use are placed in a cardboard pack.
Storage conditions
Store at a temperature not exceeding 25 °C. Keep out of the reach of children.
Best before date
2 years. Do not use after the expiration date stated on the package.
Vacation conditions
Dispensed by prescription.
Name and address of the manufacturer/organization receiving claims:
In production at Pharmstandard-Tomskkhimpharm OJSC, Russia.